A Case of Ipt

A shield of IPT 1. How and where are platelets produced in the body? Platelets are produced in the bone kernel from very large bone marrow cells called megakaryocytes. As megakaryocytes develop into gargantuan cells, they undergo a process of fragmentation that conducts in the release of oer 1,000 platelets per megakaryocyte. 2. Describe the role played by platelets in hemostasis. Platelets maintain the endothelial surface. Loss of circulating platelets quickly results in changes in the endothelial cells of the capillaries.These changes pay off intravascular material to leak into the capillary bed. Platelets initially arrest bleeding in severed kindred vessels. Platelets provide phospholipids, which acts as the catalytic surface for foundation garment of the coagulation process that played by platelets in hemostasis. 3. Define thrombopenia and list the more common causes of this condition. Thrombocytopenia is a blood disease characterized by an ab conventionalismly low teleph one number of platelets in the bloodstream.Abnormal reductions in the number of platelets are caused when abnormalities occur in any of the following three processes rock-bottom platelet production by the bone marrow increased lodging of platelets by the spleen or a more rapid than normal destruction of platelets. People with this condition easily bruise and can attain episodes of excess bleeding. 4. What are the potential consequences of a low platelet enumerate? Your blood would not clot as healthy in the pillowcase of an injury, and you could bleed to death without medical intervention. . What drugs have been associated with the development of thrombocytopenia? whatever of the drugs associated with the development of Thrombocytopenia are Sulfonylurea drugs, Benzodiazepines like Diazepam and Anti-epileptic drugs like Carbamazepine. 6. How is thrombocytopenia treated in individuals diagnosed with the condition? The type of treatment you get would estimate on the severity o f the case, but some of the possible treatments are blood or platelet transfusions, steroids, immunoglobulin, and a splenectomy. . How might removal of the spleen (splenectomy) result in an increase in the number of circulating platelets? The spleen is suppositional to remove antibodies from RBCs, so without the production of antibodies, the number of platelets should increase. 8. What is Idiopathic Thrombocytopenic Purpura (ITP)? ITP is a bleeding disorder where blood doesnt clot as well as it should due to a low number of platelets. Source bailiwick Center for Case Study Teaching in Science